Catalog Number - 85018-10P

The 85018‑10P Cogent RP C18 ABX™ HPLC Column is engineered for robust, scalable chromatography under extreme mobile phase conditions, delivering reliable performance across a wide pH range (2–12).

Built with a bulky, specially end‑capped C18 phase bonded to high‑purity silica, this column minimizes secondary interactions, improving peak shape for acidic, basic, hydrophobic, and neutral compounds, especially those with very high or very low pKa values.

✅ Ideal as a USP L1 alternate for demanding acid/base methods

100 mm Length – Increased Resolution for Method Development

• Higher resolving power than 50 mm scouting columns

• Improves separation of closely related compounds

• Increases peak capacity for complex mixtures

• Ideal for refining methods before preparative scale‑up

✅ Selected when greater resolution is needed after initial screening

4.6 mm ID – Analytical to Preparative Bridge Platform

• Compatible with standard HPLC systems

• Ideal for:

  • method development and optimization

  • scale‑up planning

  • routine analytical workflows

Typical Flow Rate Range

• ~0.8–1.5 mL/min (higher flows supported due to 10 µm particles)

✅ Enables seamless transition from analytical to preparative chromatography

10 µm Particle – Preparative Scouting & High‑Flow Performance

• Designed for:

  • High flow rates

  • Low backpressure operation

  • Durability under high sample loads

✅ Ideal for:

• Preparative method scouting

• Scale‑up method development

• Systems with pressure limitations

Wide pH Stability (pH 2–12) – Extreme Method Capability

• Designed for:

  • Acidic mobile phases

  • Basic mobile phases

• Suitable for:

  • Strong acids

  • Strong bases

✅ Enables separations not achievable with standard C18 columns

Why Choose RP C18 ABX™ Columns (10 µm)

Extreme pH Ruggedness

• Stable across full pH range (2–12)

• Ideal for harsh method conditions and difficult analytes

Preparative Scouting Capability

• Designed for method scalability and transfer

• Supports transition to prep and process chromatography

Low Backpressure Advantage

• Allows higher flow rates with minimal system strain

• Compatible with standard HPLC systems

✅ Preferred for method development where scalability is critical

Application Performance Advantages

• Suitable for:

  • Hydrophobic compounds

  • Neutral analytes

  • Long‑chain fatty acids

• Enables:

  • Reliable performance in high‑flow and scale‑up workflows

  • Consistent separations under extreme pH conditions

✅ Ideal for process development and preparative method design

System & Sample Considerations

• Compatible with standard HPLC systems

• Suitable for high‑flow analytical and preparative‑leaning workflows

Recommended sample preparation:

• 👉 Use 0.2 µm syringe filters for proper sample preparation before injection

✅ Helps:

• Prevent column fouling

• Maintain consistent performance and lifetime

Typical Applications

• Preparative method scouting

• HPLC method development

• Acidic and basic compound separations

• Pharmaceutical process development

• Stability‑indicating methods

• High‑flow analytical workflows

Important Usage Notes

• Designed for standard analytical HPLC systems (4.6 mm ID)

• Suitable for extreme pH mobile phases (pH 2–12)

• Ideal for method development and scale‑up workflows

• Optimize flow rates for throughput vs resolution balance